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Scrapy Susceptibility S905

Background

The disease scrapy occurs in sheep due to a complex interaction between genetic factors and the environment. Genetic factors influencing scrapie have been identified in the PrP-gen. There are three amino acids (136, 154 and 171) at which the genetic variation is established in the DNA test.

Result

s vary from sensitive to scrapie (V136) to resistant (R171).

Test specific information

SCRAPIE result TABLE Codon combination ???? RiskARR/ARR ???????????? ResistantARR/AHQ ???????????? ResistantARR/ARQ ???????????? Low riskARR/ARH ???????????? Low riskAHQ/AHQ ???????????? Low riskARQ/AHQ ???????????? Low riskAHQ/ARH ???????????? Low riskARH/ARH ???????????? Low riskARQ/ARH ???????????? Low riskARR/VRQ ???????????? Low riskAHQ/VRQ ???????????? Low riskARQ/ARQ ???????????? High riskARQ/VRQ ???????????? Very high riskARH/VRQ ???????????? Very high riskVRQ/VRQ ???????????? Very high riskSource: Baylis, M. et al., (2004). Risk of scrapie in British sheep of different prion protein genotype. Journal of General Virology, 85(9), 2735-2740. European Commission: The policy of breeding and genotyping of sheep, i.e. the issue of whether sheep should be bred to be resistant to scrapie.

Age

The disease may show itself on different ages, in which it cannot be estimated when the first symptoms may show themselves. Differences may exist between littermates, and between breeds.

Throughput

Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.

Location of disease or trait

This disease leads to a loss of brain function.

Breed dependence

For this test samples from all breeds are accepted.

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin. Please contact PharmaDNA if you wish to submit other material as listed.

Result

The result of the scrapy test show the genetic variation at codons 136, 154 and 171.

Inheritance

The test for scrapie is based on a combination of genetic factors in one protein. The combination is inherited together.

Severity of Disease

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