Background
Canine Leukocyte Adhesion Deficiency (CLAD) is a fatal immunodeficiency disease found in several breeds. The condition is caused by mutation in a gene encoding a leucocyte surface molecule, leading to a dysfunction of the granulocytes. Because their healing capacities are impaired, the affected dogs show severe infections. They die early in life from multiple severe infections, even if treated with massive doses of antibiotics.
Test specific information
-
Age
Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.
Throughput
Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.
Location of disease or trait
This disease leads to reduced immunity. Depending on the disease, the immune system may be completely absent.
Breed dependence
This DNA test is available for the following breeds: German Shepherd, Belgian Shepherd, Dutch Shepherd Dog.
Sample type
For this DNA test we accept the following materials: Blood EDTA, Semen, Tissue, Swab, Blood Heparin. Please contact PharmaDNA if you wish to submit other material as listed.
Result
An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.
Inheritance
This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous). Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.
Severity of Disease
-
