Background
Laxity of the hip joint is a frequent disorder in dogs. The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment. Hip Laxity has two main characteristics:
? Laxity: This can be defined by ?an abnormal freedom of movement of the bone in the hip joint?. As a result, the hip is less stable compared to healthy dogs.
? Ossification and bone formation. In younger dogs, the normal process of bone formation can be slowed down. Both Laxity and Ossifcation disorders lead to the development of artrosis when dogs mature. Dogs which are affected most can already express symptoms after a few months. Other affected dogs develop artrosis at later ages.
This marker is part of a panel of genetic factors influencing hip laxity.
Test specific information
-
Age
The disease may show itself on different ages, in which it cannot be estimated when the first symptoms may show themselves. Differences may exist between littermates, and between breeds.
Throughput
Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.
Location of disease or trait
This disease is located in the hip.
Breed dependence
For this test samples from all breeds are accepted.
Sample type
For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Swab, Tissue. Please contact PharmaDNA if you wish to submit other material as listed.
Result
The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.
This marker is part of a panel of genetic factors influencing hip laxity.
For each genetic factor of a multifactorial disease, the results are inidcated as 'Normal'. Animals carrying one copy of the undesirable genetic variant are indicated as 'Carrier', whereas animals carrying two copies of the undesirable genetic variant are indicated as 'Affected'.
Inheritance
The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.This marker is part of a panel of genetic factors influencing hip laxity.
Severity of Disease
-
