Background
The Multidrug Resistance gene 1 (the MDR1 gene) plays an important role in the barrier between blood capillaries and brain tissue. Dogs suffering from oversensitivity for Ivermectine have been documented to be susceptible to neurotoxicity induced by many other drugs as well.
Test specific information
This test is patented in certain countries. We offer our clients two options for this test because we are not allowed to perform the test in our laboratory. Firstly, the test can be ordered through a licensee of the patent owner. As a second option, the test can be forwarded to a partner laboratory in non-patented territory. Between these two options, a price difference is in place which is caused by the royalties costs on the test. The tests performed by both labs are technical identical.
Age
The genetic factor is continuously present, and will always be visible.
Throughput
Normally the result can be expected within 25 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.
Location of disease or trait
This disease leads to a loss of brain function.
Breed dependence
For this test samples from all breeds are accepted.
Sample type
For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Swab, Tissue. Please contact PharmaDNA if you wish to submit other material as listed.
Result
An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.
Inheritance
This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous). Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.
Severity of Disease
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