Background

As in humans, also in dogs obesity is associated with a variety of health problems and reduced lifespan. A considerable and increasing number of dogs is obese. However, susceptibility to obesity varies between dog breeds due to the genetic background. Labrador retrievers have the greatest documented obesity prevalence. A genetic study performed with animals of this breed and the closely related flat-coat retrievers identified a mutation, which is associated with increased body weight, adiposity and food motivation in these breeds.

Test specific information

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Age

Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.

Throughput

The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 15 working days. A longer delivery time applies to tests carried out by a Partner Lab.

Location of disease or trait

This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.

Breed dependence

This DNA test is available for the following breeds: Labrador Retriever, Flat-Coated Retriever

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Swab, Tissue.

Result

The disease is of multifactorial origin, which means that the symptoms are a result of the combination of genetic factors as well as the environment.

For each genetic factor of a multifactorial disease, a favourable allele exists. The results for this allele are inidcated as 'Normal'. Animals carrying one copy of the undesirable genetic variant are indicated as 'Carrier', whereas animals carrying two copies of the undesirable genetic variant are indicated as 'Affected'.

Inheritance

The disease is of multifactorial origin, which means that the symptoms are a combination of genetic factors as well as the environment.

Severity of Disease

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