Background
Polycystic Kidney Disease (PKD) occurs frequently in cats. During the life of an affected cat, cysts appear in the kidneys. These cysts put pressure on the healthy kidney-tissue, which leads to a loss of function of the affected kidneys. Symptoms that occur are loss of hunger, too much consumption of water and a loss of weight. Affected cats usually die at ages between four and eight years because of the kidney failure.
Test specific information
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Age
The disease may show itself on different ages, in which it cannot be estimated when the first symptoms may show themselves. Differences may exist between littermates, and between breeds.
Throughput
Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.
Location of disease or trait
This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.
Breed dependence
This DNA test is available for the following breeds: Sacred birman , Snowshoe, Turkish Van, Sphynx, Persian, Exotic cats , British Longhair, Scottish Fold.
Sample type
For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Tissue, Swab. Please contact PharmaDNA if you wish to submit other material as listed.
Result
An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population. An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will also become ill. An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will also become ill.
Inheritance
This genetic factor is inherited in an autosomal, dominant, mode. This means, that the individual can be free of the mutation (homozygote normal), affected (homozygous affected) or carrier (heterozygous affected). Both carriers and affected individuals will show symptoms of the mutation.
Severity of Disease
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